Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …

Over the course of an individual's lifetime, normal human cells accumulate mutations. Here
we compare the mutational landscape in 29 cell types from the soma and germline using …

Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …

Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …

Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …