Cancers make their own luck: theories of cancer origins
A Jassim, EP Rahrmann, BD Simons… - Nature reviews …, 2023 - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
Measuring biological aging in humans: A quest
L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
[HTML][HTML] Single-cell delineation of lineage and genetic identity in the mouse brain
During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …
The mutational landscape of human somatic and germline cells
Over the course of an individual's lifetime, normal human cells accumulate mutations. Here
we compare the mutational landscape in 29 cell types from the soma and germline using …
we compare the mutational landscape in 29 cell types from the soma and germline using …
Genetic causes and modifiers of autism spectrum disorder
L Rylaarsdam, A Guemez-Gamboa - Frontiers in cellular …, 2019 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
Single-cell sequencing techniques from individual to multiomics analyses
Y Kashima, Y Sakamoto, K Kaneko, M Seki… - … & Molecular Medicine, 2020 - nature.com
Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
The landscape of somatic mutation in normal colorectal epithelial cells
H Lee-Six, S Olafsson, P Ellis, RJ Osborne… - Nature, 2019 - nature.com
The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …
understanding the successive somatic genetic changes and consequent clonal expansions …
[HTML][HTML] Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …
Population dynamics of normal human blood inferred from somatic mutations
H Lee-Six, NF Øbro, MS Shepherd, S Grossmann… - Nature, 2018 - nature.com
Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …
dynamics have not been quantified directly in humans. Here we identified 129,582 …