One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

Stroke is associated with a limited degree of functional recovery. Imaging studies in humans
have shown that reorganization in periinfarct and connected cortical areas most closely …

NRPs (neuropilins) are co-receptors for class 3 semaphorins, polypeptides with key roles in
axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of …

Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Stroke induces axonal sprouting in peri-infarct cortex. A set of growth-associated genes
important in axonal sprouting in peripheral nervous system regeneration and cortical …

Axons in the adult mammalian central nervous system (CNS) exhibit little regeneration after
injury. It has been suggested that several axonal growth inhibitors prevent CNS axonal …