Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Plasmodium sporozoites make a remarkable journey from the mosquito midgut to the
mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is …

Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as
liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle
progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of …

The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites
(SPZs), the motile and invasive parasite stage inoculated in the host skin by infected …

Malaria infection begins when a female Anopheles mosquito injects Plasmodium
sporozoites into the skin of its host during blood feeding. Skin-deposited sporozoites may …

Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …