Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Classical schizophrenia literature reports motor symptoms as characteristic of the disorder.
After the introduction of neuroleptic drugs, the existence of genuine motor disorders was …

Dysfunction of parvalbumin (PV)-positive GABAergic interneurons (PVIs) within the
prefrontal cortex (PFC) has been implicated in schizophrenia pathology. It is however …

Motivational deficits play a central role in disability caused by schizophrenia and constitute a
major unmet therapeutic need. Negative symptoms have previously been linked to …

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments
for this devastating illness remain inadequate. Here, we critically assess rodent models and …

There is intense interest in the development and application of animal models of CNS
disorders to explore pathology and molecular mechanisms, identify potential biomarkers …

Glutamatergic neurotransmission, particularly through the N-methyl-d-aspartate (NMDA)
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …

Schizophrenia has been one of psychiatry's most contested diagnostic categories. It has
also served as a metaphor for cultural theorists to interpret modern and postmodern …

Dysregulation of the immune system contributes to the pathogenesis of neuropsychiatric
disorders including schizophrenia. Here, we demonstrated that toll-like receptor (TLR)-2, a …

Schizophrenia, a severe and debilitating disorder with a high social burden, affects 1% of
the adult world population. Available therapies are unable to treat all the symptoms, and …