Colorectal cancer is the third most common cancer in the world with increasing incidence
and mortality rates globally. Standard treatments for colorectal cancer have always been …

Recent clinical data have emphatically shown the capacity of our immune systems to
eradicate even advanced cancers. Although oncolytic viruses (OVs) were originally …

Local radiation is an established therapy for human tumors. Radiation also has been shown
to alter the phenotype of target tissue, including gene products that may make tumor cells …

Purpose: Many patients with clinically localized prostate cancer develop biochemical failure
despite excellent local therapy perhaps due to occult metastatic disease. One potential …

PURPOSE: This trial sought to determine, for the first time, the validity in human vaccinations
of using two different recombinant vaccines in diversified prime-and-boost regimens to …

Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide in human
beings. Surgery, chemotherapy, radiotherapy and targeted therapies are the conventional …

Prostvac is a prostate cancer vaccine regimen consisting of a recombinant vaccinia vector
as a primary vaccination, followed by multiple booster vaccinations employing a …

PURPOSE: Docetaxel has activity against androgen-independent prostate cancer and
preclinical studies have shown that taxane-based chemotherapy can enhance antitumor …

Purpose: Taxanes comprise some of the most widely used cancer chemotherapeutic agents.
Members of this drug family, including docetaxel, are commonly used to treat breast …

Purpose: Poxviral vectors have a proven safety record and can be used to incorporate
multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic …