Background COVID‐19 illness is highly variable, ranging from infection with no symptoms
through to pneumonia and life‐threatening consequences. Symptoms such as fever, cough …

Importance Surgeons make complex, high-stakes decisions under time constraints and
uncertainty, with significant effect on patient outcomes. This review describes the …

Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …

Background: Body temperature is commonly used to screen patients for infectious diseases,
establish diagnoses, monitor therapy, and guide management decisions. Purpose: To …

Objective To collate all available evidence on the diagnostic value of laboratory tests for the
diagnosis of serious infections in febrile children in ambulatory settings. Design Systematic …

Objective Leukaemia is the most common cancer of childhood, accounting for a third of
cases. In order to assist clinicians in its early detection, we systematically reviewed all …

Objectives Identifying infection aetiology is essential for appropriate antibiotic use. Previous
studies have shown that a host-protein signature consisting of TNF-related apoptosis …

Objective Despite the growing number of point-of-care (POC) tests available, little research
has assessed primary care clinician need for such tests. We therefore aimed to determine …

Background The prescription rate of antibiotics is high for febrile children visiting the
emergency department (ED), contributing to antimicrobial resistance. Large studies at …

Background Antibiotic resistance is a global public health issue, particularly in low-and
middle-income countries (LMICs), where antibiotics required to treat resistant infections are …