The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Nearly 40 years of research on the function of the nucleus accumbens (NAc) has provided a
wealth of information on its contributions to behavior but has also yielded controversies and …

Dopaminergic medications used in the treatment of patients with Parkinson's disease are
associated with motor and non-motor behavioural side-effects, such as dyskinesias and …

Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …

The mesolimbic dopamine system is centrally involved in reward and goal-directed
behavior, and it has been implicated in multiple psychiatric disorders. Understanding the …

There are several brain regions that have been implicated in the control of motivated
behavior and whose disruption leads to the pathophysiology observed in major psychiatric …

Excitatory projections from the prefrontal cortex (PFC) to the ventral tegmental area (VTA)
play an important role in regulating the activity of VTA neurons and the extracellular levels of …

The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as
diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated …

Background: Studies in experimental animals have implicated the mesolimbic dopaminergic
projections into the ventral striatum in the neural processes underlying behavioral …

It is commonly held that substance use comorbidity in schizophrenia represents self-
medication, an attempt by patients to alleviate adverse positive and negative symptoms …