The role of inflammation in the pathophysiology of depression and suicidal behavior: implications for treatment

G Serafini, A Costanza, A Aguglia, A Amerio… - Medical …, 2023 - medical.theclinics.com
Neuropsychiatric illnesses represent a significant cause of mortality worldwide, 1 with more
than 30% increase in recent years. Among these conditions with high socioeconomic cost …

The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings

A Chaves‐Filho, C Eyres, L Blöbaum… - Journal of …, 2024 - Wiley Online Library
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …

Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social …

FG Ibáñez, T Halvorson, K Sharma, CG McKee… - Brain, Behavior, and …, 2023 - Elsevier
Psychological stress confers an increased risk for several diseases including psychiatric
conditions. The susceptibility to psychological stress is modulated by various factors, many …

Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint …

L Naggan, E Robinson, E Dinur, H Goldenberg… - Brain, behavior, and …, 2023 - Elsevier
Background Bipolar disorder (BD) is associated with marked functional impairments along
with increased rate of suicide. Although there is ample evidence for the involvement of …

[HTML][HTML] Using focused ultrasound to modulate microglial structure and function

S Grewal, E Gonçalves de Andrade… - Frontiers in Cellular …, 2023 - frontiersin.org
Transcranial focused ultrasound (FUS) has the unique ability to target regions of the brain
with high spatial precision, in a minimally invasive manner. Neuromodulation studies have …

The missing piece? A case for microglia's prominent role in the therapeutic action of anesthetics, ketamine, and psychedelics

J VanderZwaag, T Halvorson, K Dolhan… - Neurochemical …, 2023 - Springer
There is much excitement surrounding recent research of promising, mechanistically novel
psychotherapeutics–psychedelic, anesthetic, and dissociative agents–as they have …

Associations of the immune system in aggression traits and the role of microglia as mediators

A Takahashi - Neuropharmacology, 2024 - Elsevier
There is an important relationship between the immune system and aggressive behavior.
Aggressive encounters acutely increase the levels of proinflammatory cytokines, and there …

[HTML][HTML] The implication of a diversity of non-neuronal cells in disorders affecting brain networks

M Carrier, K Dolhan, BC Bobotis… - Frontiers in Cellular …, 2022 - frontiersin.org
In the central nervous system (CNS) neurons are classically considered the functional unit of
the brain. Analysis of the physical connections and co-activation of neurons, referred to as …

Transcriptional patterns of brain structural covariance network abnormalities associated with suicidal thoughts and behaviors in major depressive disorder

K Qin, H Li, H Zhang, L Yin, B Wu, N Pan, T Chen… - Biological …, 2024 - Elsevier
Background Although brain structural covariance network (SCN) abnormalities have been
associated with suicidal thoughts and behaviors (STBs) in individuals with major depressive …

[HTML][HTML] Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex …

N Bencze, B Scheich, É Szőke, I Wilhelm, S Körmöndi… - Cancers, 2024 - mdpi.com
Simple Summary Bone cancer-related chronic pain is mediated by central sensitization
involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the …