The role of inflammation in the pathophysiology of depression and suicidal behavior: implications for treatment
G Serafini, A Costanza, A Aguglia, A Amerio… - Medical …, 2023 - medical.theclinics.com
Neuropsychiatric illnesses represent a significant cause of mortality worldwide, 1 with more
than 30% increase in recent years. Among these conditions with high socioeconomic cost …
than 30% increase in recent years. Among these conditions with high socioeconomic cost …
The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings
A Chaves‐Filho, C Eyres, L Blöbaum… - Journal of …, 2024 - Wiley Online Library
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …
adulthood, which follows a progressive course throughout life. Replicated epidemiological …
Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social …
Psychological stress confers an increased risk for several diseases including psychiatric
conditions. The susceptibility to psychological stress is modulated by various factors, many …
conditions. The susceptibility to psychological stress is modulated by various factors, many …
Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint …
Background Bipolar disorder (BD) is associated with marked functional impairments along
with increased rate of suicide. Although there is ample evidence for the involvement of …
with increased rate of suicide. Although there is ample evidence for the involvement of …
[HTML][HTML] Using focused ultrasound to modulate microglial structure and function
S Grewal, E Gonçalves de Andrade… - Frontiers in Cellular …, 2023 - frontiersin.org
Transcranial focused ultrasound (FUS) has the unique ability to target regions of the brain
with high spatial precision, in a minimally invasive manner. Neuromodulation studies have …
with high spatial precision, in a minimally invasive manner. Neuromodulation studies have …
The missing piece? A case for microglia's prominent role in the therapeutic action of anesthetics, ketamine, and psychedelics
J VanderZwaag, T Halvorson, K Dolhan… - Neurochemical …, 2023 - Springer
There is much excitement surrounding recent research of promising, mechanistically novel
psychotherapeutics–psychedelic, anesthetic, and dissociative agents–as they have …
psychotherapeutics–psychedelic, anesthetic, and dissociative agents–as they have …
Associations of the immune system in aggression traits and the role of microglia as mediators
A Takahashi - Neuropharmacology, 2024 - Elsevier
There is an important relationship between the immune system and aggressive behavior.
Aggressive encounters acutely increase the levels of proinflammatory cytokines, and there …
Aggressive encounters acutely increase the levels of proinflammatory cytokines, and there …
[HTML][HTML] The implication of a diversity of non-neuronal cells in disorders affecting brain networks
M Carrier, K Dolhan, BC Bobotis… - Frontiers in Cellular …, 2022 - frontiersin.org
In the central nervous system (CNS) neurons are classically considered the functional unit of
the brain. Analysis of the physical connections and co-activation of neurons, referred to as …
the brain. Analysis of the physical connections and co-activation of neurons, referred to as …
Transcriptional patterns of brain structural covariance network abnormalities associated with suicidal thoughts and behaviors in major depressive disorder
Background Although brain structural covariance network (SCN) abnormalities have been
associated with suicidal thoughts and behaviors (STBs) in individuals with major depressive …
associated with suicidal thoughts and behaviors (STBs) in individuals with major depressive …
[HTML][HTML] Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex …
N Bencze, B Scheich, É Szőke, I Wilhelm, S Körmöndi… - Cancers, 2024 - mdpi.com
Simple Summary Bone cancer-related chronic pain is mediated by central sensitization
involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the …
involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the …