As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Transplantation of in-vitro-generated organ buds is a promising approach toward
regenerating functional and vascularized organs. Though it has been recently shown in the …

Motor proteins are involved in a wide range of cellular and subcellular movements. Recent
studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in …

Background Epithelial invagination is a fundamental morphogenetic behavior that
transforms a flat cell sheet into a pit or groove. Previous studies of invagination have focused …

Mammalian septin SEPT2 belongs to a conserved family of filamentous GTPases that are
associated with actin stress fibers in interphase cells and the contractile ring in dividing cells …

Wild organisms are under increasing pressure to adapt rapidly to environmental changes.
Predicting the impact of these changes on natural populations requires an understanding of …

The assembly and mechanics of actomyosin stress fibers (SFs) depend on myosin
regulatory light chain (RLC) phosphorylation, which is driven by myosin light chain kinase …

Abnormally stiff substrates have been shown to trigger cancer progression. However, the
detailed molecular mechanisms underlying this trigger are not clear. In this study, we …

Physical properties of the extracellular matrix (ECM) can control cellular phenotypes via
mechanotransduction, which is the process of translation of mechanical stresses into …

Smooth muscle contraction is activated primarily by phosphorylation at S19 of the 20‐kDa
regulatory light chain subunits of myosin II (LC20) catalyzed by Ca2+/calmodulin‐dependent …