Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …

A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …

Introduction: Alzheimer's disease is primarily a dementia-related disorder from progressive
cognitive deterioration and memory impairment, while Parkinson's disease is primarily a …

Cognitive impairment is a common non-motor symptom in Parkinson's Disease (PD) and an
important source of patient disability and caregiver burden. The timing, profile and rate of …

Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative
disorder, affecting 1% of the population after the age of about 60 years old and 4% of those …

Mitochondrial complex I deficiency occurs in the substantia nigra of individuals with
Parkinson's disease. It is generally believed that this phenomenon is caused by …