Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …

Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly
a reflection of its synthetic capacity, we measured the levels and activity of γ …

Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …

Oxidative stress has been associated with the onset and progression of mild cognitive
impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display …

Background: Aging is associated with oxidative stress, but underlying mechanisms remain
poorly understood. Objective: We tested whether glutathione deficiency occurs because of …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …

Glutathione plays a critical role in many biological processes both directly as a co-factor in
enzymatic reactions and indirectly as the major thiol-disulfide redox buffer in mammalian …