Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

COVID-19: Transmission, prevention, and potential therapeutic opportunities

M Lotfi, MR Hamblin, N Rezaei - Clinica chimica acta, 2020 - Elsevier
The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), remains a global challenge. Despite intense …

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

The role of NO in COVID-19 and potential therapeutic strategies

W Fang, J Jiang, L Su, T Shu, H Liu, S Lai… - Free radical biology and …, 2021 - Elsevier
Nitric oxide (NO) is a free radical playing an important pathophysiological role in
cardiovascular and immune systems. Recent studies reported that NO levels were …

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

S Sharma, T Tyagi, S Antoniak - Frontiers in immunology, 2022 - frontiersin.org
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Pharmacological treatments of COVID-19

A Sahebnasagh, R Avan, F Saghafi… - Pharmacological …, 2020 - Springer
The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19),
which was reported for the first time in December 2019, was named by the World Health …

Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms

MR Garren, M Ashcraft, Y Qian, M Douglass… - Applied materials …, 2021 - Elsevier
Nitric oxide (NO) is a gasotransmitter of great significance to developing the innate immune
response to many bacterial and viral infections, while also modulating vascular physiology …

[HTML][HTML] Nitric oxide (NO) and nanoparticles–potential small tools for the war against COVID-19 and other human coronavirus infections

JC Pieretti, O Rubilar, RB Weller, GR Tortella… - Virus research, 2021 - Elsevier
The endogenous free radical nitric oxide (NO) plays a pivotal role in the immunological
system. NO has already been reported as a potential candidate for use in the treatment of …

Nitric oxide: clinical applications in critically ill patients

S Redaelli, A Magliocca, R Malhotra, G Ristagno… - Nitric Oxide, 2022 - Elsevier
Inhaled nitric oxide (iNO) acts as a selective pulmonary vasodilator and it is currently
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …

The potential role of nitric oxide as a therapeutic agent against SARS-CoV-2 infection

S Xiao, Z Yuan, Y Huang - International Journal of Molecular Sciences, 2023 - mdpi.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the greatest worldwide …