Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

The intestine is one of the major organs in C. elegans and is largely responsible for food
digestion and assimilation as well as the synthesis and storage of macromolecules. In …

Dendritic spines, the postsynaptic compartments of excitatory neurotransmission, have
different shapes classified from 'stubby'to 'mushroom-like'. Whereas mushroom spines are …

This chapter focuses on the introduction of molecular signaling pathways involved in
regulating the toxicity of environmental toxicants or stresses in Caenorhabditis elegans …

Calreticulin is a 46-kDa Ca2+-binding chaperone found across a diverse range of species.
The protein is involved in the regulation of intracellular Ca2+ homeostasis and endoplasmic …

In C. elegans, a hyperactivated MEC-4 (d) ion channel induces necrotic-like neuronal death
that is distinct from apoptosis. We report that null mutations in calreticulin suppress both mec …

The increasing of intracellular calcium concentration is a fundamental process for mediating
osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium …

Individually, dysfunction of both the endoplasmic reticulum (ER) and mitochondria has been
linked to aging, but how communication between these organelles might be targeted to …

The exposure of calreticulin (CRT) on the surface of stressed and dying cancer cells
facilitates their uptake by dendritic cells and the subsequent presentation of tumor …

Charles Darwin first provided a lucid explanation of how gender differences evolve nearly
140 years ago. Yet, a disconnect remains between his theory of sexual selection and the …