Vibrational optical activity (VOA) refers to two vibrational techniques: vibrational circular
dichroism (VCD) and Raman optical activity (ROA) that are sensitive both to the chirality and …

Nature is an important inspirational source for scientists, and presents complex and elegant
examples of adaptive and intelligent systems created by self-assembly. Significant effort has …

The unique enhanced sensitivity of vibrational circular dichroism (VCD) to the formation and
development of amyloid fibrils in solution is extended to four additional fibril-forming proteins …

The neuropathology of Alzheimer's disease (AD) is characterized by hyperphosphorylated
tau neurofibrillary tangles (NFTs) and amyloid-beta (Aβ) plaques. Aβ plaques are …

Vibrational circular dichroism (VCD) spectroscopy is an extension of circular dichroism
spectroscopy into the infrared and near-infrared regions where vibrational transitions occur …

Polyglutamine (polyQ) sequences are found in a variety of proteins, and mutational
expansion of the polyQ tract is associated with many neurodegenerative diseases. We study …

Identifying the structures of membrane bound proteins is critical to understanding their
function in healthy and diseased states. We introduce a surface enhanced Raman …

We demonstrate that molecular vibrations with originally low or zero intensity in a vibrational
circular dichroism (VCD) spectrum attain chirality in molecular crystals by coordinated …

Amyloid fibrils are supramolecular systems showing distinct chirality at different levels of
their complex multilayered architectures. Due to the regular long‐range chiral organization …

Amyloid fibril formation occurs in restricted environment, such as the interface between
intercellular fluids and bio-membranes. Conformational interconversion from α-helix to β …