Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

The histone variant H3. 3 marks active chromatin by replacing the conventional histone H3.
1. In this study, we investigate the detailed mechanism of H3. 3 replication-independent …

Studies that concern the mechanism of DNA replication have provided a major framework
for understanding genetic transmission through multiple cell cycles. Recent work has begun …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The centromere is responsible for accurate chromosome segregation. Mammalian
centromeres are specified epigenetically, with all active centromeres containing centromere …

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated
by kinetochores, which are unique chromosomal sites for microtubule attachment …

The assembly of just a single kinetochore at the centromere of each sister chromatid is
essential for accurate chromosome segregation during cell division. Surprisingly, despite …