A growing body of clinical literature emphasizes the impact of cerebral edema in early brain
injury following aneurysmal subarachnoid hemorrhage (aSAH). Aneurysm rupture itself …

Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke associated with high
mortality and morbidity. The blood-brain-barrier (BBB) is a structure consisting primarily of …

Objective To investigate whether spreading depolarization (SD)-related variables at 2
different time windows (days 1–4 and 5–8) after aneurysmal subarachnoid hemorrhage …

BACKGROUND AND PURPOSE: Neuropsychiatric systemic lupus erythematosus refers to
central and peripheral nervous system involvement, which may occur secondary to …

Unfavorable venous outflow (VO) is associated with cerebral edema, which represents
microvascular dysfunction. This study estimated the relationship between VO and …

Purpose Blood–tumor barrier is a limiting factor for effectiveness of systemic therapy to brain
metastases. This study aimed to assess the extent and time course of BTB opening in BM …

OBJECTIVE. The current understanding of the utility of blood-brain barrier permeability
(BBBP) evaluation with extended-pass perfusion CT in the clinical setting is limited. We …

Preventing secondary brain injury after neurological insults is one of the primary goals of the
neurocritical care unit. Our understanding of the roles of intracranial pressure (ICP) and …

Severe traumatic brain injury (TBI) produces shearing forces on long-range axons and brain
vessels, causing axonal and vascular injury. To examine whether microbleeds and axonal …