Role of Janus kinase 3 in predisposition to obesity-associated metabolic syndrome
Obesity, a worldwide epidemic, is a major risk factor for the development of metabolic
syndrome (MetS) including diabetes and associated health complications. Recent studies …
syndrome (MetS) including diabetes and associated health complications. Recent studies …
Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin
Compromise in adherens junctions (AJs) is associated with several chronic inflammatory
diseases. We reported previously that Janus kinase 3, a non-receptor tyrosine kinase, plays …
diseases. We reported previously that Janus kinase 3, a non-receptor tyrosine kinase, plays …
Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
Background and Aims: A compromise in intestinal mucosal functions is associated with
several chronic inflammatory diseases. Previously, we reported that obese humans have a …
several chronic inflammatory diseases. Previously, we reported that obese humans have a …
Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity
Breast cancer resistance protein (BCRP) is a member of ATP-binding cassette (ABC)
transporter proteins whose primary function is to efflux substrates bound to the plasma …
transporter proteins whose primary function is to efflux substrates bound to the plasma …
Structure and Function of Jak3-SH2 Domain
Abstract Janus kinase 3 (Jak3) is a non-receptor tyrosine kinase expressed in hematopoietic
and non-hematopoietic cells. Though expression of Jak3 is necessary for adaptive immune …
and non-hematopoietic cells. Though expression of Jak3 is necessary for adaptive immune …