This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Lipids, the basic components of the cell membrane, execute fundamental roles in almost all
the cell activities including cell-cell recognition, signalling transduction and energy supplies …

Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and
development, but also sensitizes the function of various immune cells in the immune …

Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid
peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of …

Tumor cells, including cancer stem cells (CSCs) resistant to radio-and chemotherapy, must
enhance metabolism to meet the extra energy demands to repair and survive such …

Simple Summary Drug therapy is an important treatment for cancer patients; however, drug
resistance severely affects the survival time and quality of life of cancer patients. Oxidative …

Stem cells give rise to all cells and build the tissue structures in our body, and heterogeneity
and plasticity are the hallmarks of stem cells. Epigenetic modification, which is associated …

Objective: To investigate the exact role of GRP78 in artesunate-induced ferroptosis in KRAS
mutant pancreatic cancer cells. Methods: Artesunate-induced KRAS mutant human …