Epigenetics of aging and aging-associated diseases

D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Lipids as regulators of cellular senescence

S Hamsanathan, AU Gurkar - Frontiers in physiology, 2022 - frontiersin.org
Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

P16INK4A—more than a senescence marker

H Safwan-Zaiter, N Wagner, KD Wagner - Life, 2022 - mdpi.com
Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Histone modifications as an intersection between diet and longevity

D Molina-Serrano, D Kyriakou, A Kirmizis - Frontiers in genetics, 2019 - frontiersin.org
Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Potential micronutrients and phytochemicals against the pathogenesis of chronic obstructive pulmonary disease and lung cancer

T Zhai, S Li, W Hu, D Li, S Leng - Nutrients, 2018 - mdpi.com
Lung cancer and chronic obstructive pulmonary disease have shared etiology, including key
etiological changes (eg, DNA damage and epigenetics change) and lung function …

[HTML][HTML] D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

X Xu, X Shen, W Feng, D Yang, L Jin, J Wang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Treatment of glioblastoma using radiotherapy and chemotherapy has various
outcomes, key among them being cellular senescence. However, the molecular …

Hepatic senescence accompanies the development of NAFLD in non-aged mice independently of obesity

II Moustakas, A Katsarou, AI Legaki, I Pyrina… - International journal of …, 2021 - mdpi.com
Senescence is considered to be a cardinal player in several chronic inflammatory and
metabolic pathologies. The two dominant mechanisms of senescence include replicative …

The potential role of nutrition in lung cancer establishment and progression

C Porro, ME La Torre, N Tartaglia, T Benameur… - Life, 2022 - mdpi.com
Lung cancer is a devastating disease with a high incidence and low survival rates, so recent
studies have focused on analyzing the risk factors that might prevent this disease from …

[HTML][HTML] β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling

D Yang, X Xu, X Wang, W Feng, X Shen… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Glioma is currently the most widespread and malignant primary intracranial tumor, which is
characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive …

Lipids and the hallmarks of ageing: from pathology to interventions

R Sharma, B Diwan - Mechanisms of Ageing and Development, 2023 - Elsevier
Lipids are critical structural and functional architects of cellular homeostasis. Change in
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …