Epigenetics of aging and aging-associated diseases
D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Lipids as regulators of cellular senescence
S Hamsanathan, AU Gurkar - Frontiers in physiology, 2022 - frontiersin.org
Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …
maintaining structural integrity of membranes, energy storage, to signaling molecules …
P16INK4A—more than a senescence marker
H Safwan-Zaiter, N Wagner, KD Wagner - Life, 2022 - mdpi.com
Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …
Histone modifications as an intersection between diet and longevity
D Molina-Serrano, D Kyriakou, A Kirmizis - Frontiers in genetics, 2019 - frontiersin.org
Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …
gene transcription, thereby impacting on various important cellular phenotypes. Over the …
Potential micronutrients and phytochemicals against the pathogenesis of chronic obstructive pulmonary disease and lung cancer
Lung cancer and chronic obstructive pulmonary disease have shared etiology, including key
etiological changes (eg, DNA damage and epigenetics change) and lung function …
etiological changes (eg, DNA damage and epigenetics change) and lung function …
[HTML][HTML] D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway
X Xu, X Shen, W Feng, D Yang, L Jin, J Wang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Treatment of glioblastoma using radiotherapy and chemotherapy has various
outcomes, key among them being cellular senescence. However, the molecular …
outcomes, key among them being cellular senescence. However, the molecular …
Hepatic senescence accompanies the development of NAFLD in non-aged mice independently of obesity
II Moustakas, A Katsarou, AI Legaki, I Pyrina… - International journal of …, 2021 - mdpi.com
Senescence is considered to be a cardinal player in several chronic inflammatory and
metabolic pathologies. The two dominant mechanisms of senescence include replicative …
metabolic pathologies. The two dominant mechanisms of senescence include replicative …
The potential role of nutrition in lung cancer establishment and progression
Lung cancer is a devastating disease with a high incidence and low survival rates, so recent
studies have focused on analyzing the risk factors that might prevent this disease from …
studies have focused on analyzing the risk factors that might prevent this disease from …
[HTML][HTML] β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling
D Yang, X Xu, X Wang, W Feng, X Shen… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Glioma is currently the most widespread and malignant primary intracranial tumor, which is
characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive …
characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive …
Lipids and the hallmarks of ageing: from pathology to interventions
R Sharma, B Diwan - Mechanisms of Ageing and Development, 2023 - Elsevier
Lipids are critical structural and functional architects of cellular homeostasis. Change in
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …