Structure‐based design of inhibitors of protein–protein interactions: mimicking peptide binding epitopes

M Pelay‐Gimeno, A Glas, O Koch… - Angewandte Chemie …, 2015 - Wiley Online Library
Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Polyproline-II helix in proteins: structure and function

AA Adzhubei, MJE Sternberg, AA Makarov - Journal of molecular biology, 2013 - Elsevier
The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

Mechanisms underlying ubiquitination

CM Pickart - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Assembly of cell regulatory systems through protein interaction domains

T Pawson, P Nash - science, 2003 - science.org
The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

[HTML][HTML] Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

S Naisbitt, E Kim, JC Tu, B Xiao, C Sala, J Valtschanoff… - Neuron, 1999 - cell.com
NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-
95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed …

The importance of being proline: the interaction of proline‐rich motifs in signaling proteins with their cognate domains

BK Kay, MP Williamson, M Sudol - The FASEB journal, 2000 - Wiley Online Library
ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)

AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - ASPET
The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Mechanism and role of PDZ domains in signaling complex assembly

BZ Harris, WA Lim - Journal of cell science, 2001 - journals.biologists.com
PDZ domains are protein-protein recognition modules that play a central role in organizing
diverse cell signaling assemblies. These domains specifically recognize short C-terminal …

Protein–protein interactions define specificity in signal transduction

T Pawson, P Nash - Genes & development, 2000 - genesdev.cshlp.org
Virtually every aspect of cellular function within a metazoan organism, including proliferative
status, metabolism, gene expression, cytoskeletal organization, and indeed the cell's very …