The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Biological clocks are autonomous anticipatory oscillators that play a critical role in the
organization and information processing from genome to whole organisms. Transformative …

INTRODUCTION Temporally consolidated behaviors such as sleep normally occur in
synchrony with endogenous circadian rhythms and both have been reported to contribute to …

Traditionally studies of brain function have focused on task-evoked responses. By their very
nature such experiments tacitly encourage a reflexive view of brain function. While such an …

Brain aging is associated with diminished circadian clock output and decreased expression
of the core clock proteins, which regulate many aspects of cellular biochemistry and …

Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …

The past twenty years have witnessed the most remarkable breakthroughs in our
understanding of the molecular and cellular mechanisms that underpin circadian …

High-resolution molecular and imaging techniques are shedding light on the mechanisms
and functional significance of the transient rise in tissue lactate that accompanies synaptic …

Neuroprotectant strategies that have worked in rodent models of stroke have failed to
provide protection in clinical trials. Here we show that the opposite circadian cycles in …