Niemann-Pick disease type C (NP-C) is a rare, progressive, irreversible disease leading to
disabling neurological manifestations and premature death. The estimated disease …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

N-type voltage-gated calcium (Ca V) channels mediate Ca 2+ influx at presynaptic terminals
in response to action potentials and play vital roles in synaptogenesis, release of …

Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine,
industry and basic sciences owing to their ability to solubilize and stabilize guest …

High-voltage-activated R-type CaV2. 3 channel plays pivotal roles in many physiological
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …

Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their
ability to complex with hydrophobic molecules. One cyclodextrin in particular, 2 …

Background The implication of ion channels and inositol 1, 4, 5-trisphosphate (IP 3)-induced
Ca 2+ signalling (IICS) in the carcinogenesis processes, including deregulation of cell …

Cholesterol is a major component of plasma membranes and plays a significant role in
actively regulating the functioning of several membrane proteins in humans. In this study, we …

In this study, we investigated the effects of membrane cholesterol content on the mechanical
properties of cell membranes by using optical tweezers. We pulled membrane tethers from …

There is increasing evidence that the lysosome is involved in the pathogenesis of a variety
of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the …