Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …

Matrix stiffness (resistance to deformation), one of the many mechanical forces acting on
cells, is increasingly appreciated as an important mediator of cell behavior. It regulates cell …

Liver fibrosis, the response to chronic liver injury, results from the activation of mesenchymal
cells to fibrogenic myofibroblasts. We have recently shown that two key myofibroblast …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Recent studies indicate that the biophysical properties of the cellular microenvironment
strongly influence a variety of fundamental cell behaviors. The extracellular matrix's (ECM) …

Increased vascular stiffness is fundamental to hypertension, and its complications, including
atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather …

Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the
response of the liver to cytokines. However, it is well established that hepatocytes cultured …

To engineer complex tissues, it is necessary to create hybrid scaffolds with micropatterned
structural and biomechanical properties, which can closely mimic the intricate body tissues …

During the development of atherosclerosis and other vascular diseases, vascular smooth
muscle cells (SMCs) located in the intima and media of blood vessels shift from a contractile …

Osteogenic cells respond to mechanical changes in their environment by altering their
spread area, morphology, and gene expression profile. In particular, the bulk modulus of the …