The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

Voltage-dependent anion channel (VDAC), the most abundant mitochondrial outer
membrane protein, is important for a variety of mitochondrial functions including metabolite …

Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ
dysfunction with elusive underlying mechanisms and limited treatment options. In this study …

Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics
are commonly used to evaluate the conditions of various diseases especially in tumors …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …

The voltage-dependent anion channel (VDAC) is one of the most highly abundant proteins
found in the outer mitochondrial membrane, and was one of the earliest discovered. Here …