5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a
peripheral hormone. Most of the body's serotonin is circulating in the bloodstream …

Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …

Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Since its identification, 75 years ago, the monoamine serotonin (5-HT) has attracted
considerable attention toward its role as a neurotransmitter in the central nervous system …

Serotonylation, the covalent linkage of serotonin to proteins has been discovered more than
60 years ago but only recently the mechanisms and first functions have been elucidated. It …