The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …

There is a longstanding association between substance-use disorders (SUDs) and the
psychological construct of impulsivity. In the first section of this review, personality and …

Genetic variation may partially underlie complex personality and physiological traits—such
as impulsivity, risk taking and stress responsivity—as well as a substantial proportion of …

The dopaminergic system plays a pivotal role in the central nervous system via its five
diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many …

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …

Repeated exposure to drugs of abuse produces long‐term molecular and neurochemical
changes that may explain the core features of addiction, such as the compulsive seeking …

Molecular genetic studies of personality began with two high impact papers in 1996 that
showed provisional associations between the dopamine DRD4 exon III repeat region and …

Currently available treatments have limited pro-cognitive effects for neuropsychiatric
disorders, such as schizophrenia, Parkinson's disease and Alzheimer's disease. The …

309 Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and
anti- reward systems Mark S. Gold8, K Page 1 309 Molecular role of dopamine in anhedonia …

BACKGROUND: The purpose of this review is to systematically appraise the peer-reviewed
literature about the genetic and environmental determinants of psychiatric comorbidity …