Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …

The capability of carbohydrate utilization in fish is limited compared to mammals. It has
scientific and practical significance to improve the ability of fish to use carbohydrates. The …

In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …

BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1
diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central
nervous system that also act in the pancreas as peripheral regulators of metabolism …

Pancreatic beta cells are the only cell type in our body capable of producing and secreting
insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after …

Key points We used a mouse expressing a light‐sensitive ion channel in β‐cells to
understand how α‐cell activity is regulated by β‐cells. Light activation of β‐cells triggered a …