Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …