Higher-order organization of biomolecular condensates
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets
R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023 - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
Post-translational modifications of histones that influence nucleosome dynamics
GD Bowman, MG Poirier - Chemical reviews, 2014 - ACS Publications
Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
RING domain E3 ubiquitin ligases
RJ Deshaies, CAP Joazeiro - Annual review of biochemistry, 2009 - annualreviews.org
E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …
Transcriptional elongation control in developmental gene expression, aging, and disease
Y Aoi, A Shilatifard - Molecular cell, 2023 - cell.com
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …
regulation of gene expression in response to developmental and environmental cues in …
Role of histone H2A ubiquitination in Polycomb silencing
H Wang, L Wang, H Erdjument-Bromage, M Vidal… - Nature, 2004 - nature.com
Covalent modification of histones is important in regulating chromatin dynamics and
transcription,. One example of such modification is ubiquitination, which mainly occurs on …
transcription,. One example of such modification is ubiquitination, which mainly occurs on …
Histones: annotating chromatin
EI Campos, D Reinberg - Annual review of genetics, 2009 - annualreviews.org
Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …
structured and maneuvered to elicit cellular processes, including transcription, cell division …
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
Y Wang, L Yang, X Zhang, W Cui, Y Liu, QR Sun… - EMBO …, 2019 - embopress.org
Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …
Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer
Histone post-transcriptional modifications play essential roles in regulation of all DNA
related processes. Among them, histone ubiquitination has been discovered for more than …
related processes. Among them, histone ubiquitination has been discovered for more than …