Protein turnover reflects the balance between synthesis and degradation of proteins, and it
is a crucial process for the maintenance of the cellular protein pool. The folding of proteins …

We have recently proposed a common mechanistic pathway by which obesity and
hypertension lead to increased renal cell cancer risk. Our hypothesis posits lipid …

Mitochondria are involved in many cellular processes; mitochondrial dysfunctions have
been associated with apoptosis, aging, and a number of pathological conditions, including …

BACKGROUND AND PURPOSE Efavirenz (EFV) is widely used in the treatment of HIV‐1
infection. Though highly efficient, there is growing concern about EFV‐related side effects …

The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies
reported that Ca2+, cytochrome c, and caspase activation play a role in Salinomycin …

Neutrophils play a central role in the innate immune response and a critical role in bacterial
killing. Most studies of neutrophil function have been conducted under conditions of ambient …

Accumulating evidence suggests that enhanced peroxidative damage caused by reactive
oxygen species (ROS) may contribute to the pathogenesis of cisplatin-induced acute renal …

NeuroD2 is sufficient to induce cell cycle arrest and neurogenic differentiation in
nonneuronal cells. To determine whether this bHLH transcription factor was necessary for …

Background Cells treated with hsp90 inhibitors exhibit pleiotropic changes, including an
expansion of the mitochondrial compartment, accompanied by mitochondrial fragmentation …

Multiparametric silicon sensor chips mounted into biocompatible cell culture units have been
used for investigations on cellular microphysiological patterns. Potentiometric, amperometric …