Delayed neurological deterioration after subarachnoid haemorrhage

RL Macdonald - Nature Reviews Neurology, 2014 - nature.com
Subarachnoid haemorrhage (SAH) causes early brain injury (EBI) that is mediated by effects
of transient cerebral ischaemia during bleeding plus effects of the subarachnoid blood …

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Á Chamorro, U Dirnagl, X Urra, AM Planas - The Lancet Neurology, 2016 - thelancet.com
Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …

ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury

DW Wright, AL Kellermann, VS Hertzberg… - Annals of emergency …, 2007 - Elsevier
STUDY OBJECTIVE: Laboratory evidence indicates that progesterone has potent
neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential …

The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters

MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury

FA Sehba, RM Pluta, JH Zhang - Molecular neurobiology, 2011 - Springer
Delayed vasospasm that develops 3–7 days after aneurysmal subarachnoid hemorrhage
(SAH) has traditionally been considered the most important determinant of delayed ischemic …

Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

N Marklund, L Hillered - British journal of pharmacology, 2011 - Wiley Online Library
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults.
Survivors of TBI frequently suffer from long‐term personality changes and deficits in …

Magnesium—essentials for anesthesiologists

S Herroeder, ME Schönherr, SG De Hert… - The Journal of the …, 2011 - pubs.asahq.org
Magnesium plays a fundamental role in many cellular functions, and thus there is increasing
interest in its role in clinical medicine. Although numerous experimental studies indicate …

[PDF][PDF] A brief review of traumatic brain injury rehabilitation

KSG Chua, YS Ng, SGM Yap, CW Bok - Annals-Academy of …, 2007 - annals.edu.sg
Introduction: This article aims to provide an overview of the epidemiology, medical and
rehabilitation issues, current evidence for traumatic brain injury (TBI) rehabilitation, recent …

Magnesium as a neuroprotective agent: a review of its use in the fetus, term infant with neonatal encephalopathy, and the adult stroke patient

I Lingam, NJ Robertson - Developmental neuroscience, 2018 - karger.com
Magnesium is an intracellular cation essential for many en-zymatic processes and cellular
functions. Magnesium sulfate acts as an endogenous calcium channel antagonist at …

Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N‐acetylcysteine

G Chen, J Shi, Z Hu, C Hang - Mediators of inflammation, 2008 - Wiley Online Library
Although N‐acetylcysteine (NAC) has been shown to be neuroprotective for traumatic brain
injury (TBI), the mechanisms for this beneficial effect are still poorly understood. Cerebral …