Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Glycosylation processes are under high natural selection pressure, presumably because
these can modulate resistance to infection. Here, we asked whether inactivation of the UDP …

Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into
the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a …

Clinical malaria is associated with the proliferation of Plasmodium parasites in human
erythrocytes. The coordinated processes of parasite egress from and invasion into …

Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca2+ from
intracellular stores to activate stage-specific Ca2+-dependent protein kinases. Using the …

Malaria infection is initiated when Anopheles mosquitoes inject Plasmodium sporozoites
into the skin. Sporozoites subsequently reach the liver, invading and developing within …

Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan
parasites, yet the key mediators that transduce these signals remain largely unknown. One …

Calcium-dependent protein kinases (CDPKs) are important sensors of Ca+ 2 flux in plants,
which control plant development and responses by regulating downstream components of …