Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

M Shi, Z Chen, H Gong, Z Peng, Q Sun… - Phytotherapy …, 2024 - Wiley Online Library
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …

A review on the neurotoxic effects of doxorubicin

K Kamińska, A Cudnoch-Jędrzejewska - Neurotoxicity Research, 2023 - Springer
Anthracyclines, a class of drugs considered as most effective anticancer drugs, used in the
various regimens of cancer chemotherapy, induce long-term impairment of mitochondrial …

Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection

RL Younis, RM El-Gohary, AA Ghalwash… - Neurochemical …, 2024 - Springer
Luteolin is an essential natural polyphenol found in a variety of plants. Numerous studies
have supported its protective role in neurodegenerative diseases, yet the research for its …

Rational design of copper (i)-doped metal–organic frameworks as dual-functional nanocarriers for combined chemo–chemodynamic therapy

L Yao, B Chen, H Wu, Y Cui, G Qian - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Combination therapies are an increasingly important part of the antitumor medicine
armamentarium. However, developing desirable nanomaterials for combination therapies is …

Dose-dependent manner of luteolin in the modulation of spatial memory with respect to the hippocampal level of HSP70 and HSP90 in sleep-deprived rats

P Rahimpour, M Nasehi, MR Zarrindast, S Khalifeh - Gene, 2023 - Elsevier
Sleep deprivation (SD) induces a variety of deleterious effects on different cognitive
functions such as memory. Elevated neuroinflammation, oxidative stress, and apoptosis, and …

Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation

SE Owumi, GE Adebisi, OA Odunola - Chemico-Biological Interactions, 2023 - Elsevier
Abstract The “anthracycline, Epirubicin (EPI),” in managing breast cancer, is highly cytotoxic.
Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its …

Phytochemicals, Biological Activities, Molecular Mechanisms, and Future Prospects of Plantago asiatica L.

SY Wen, BY Wei, JQ Ma, L Wang… - Journal of Agricultural …, 2022 - ACS Publications
Plantago asiatica L. has been used as a vegetable and nutritious food in Asia for thousands
of years. According to recent phytochemical and pharmacological research, the active …

Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats' hepatorenal function altering oxidative, inflammatory, and apoptotic balance

SE Owumi, UO Arunsi, OM Oyewumi… - BMC Pharmacology and …, 2022 - Springer
Inadvertent exposure to furan and Pb is associated with hepatorenal abnormalities in
humans and animals. It is perceived that these two chemical species may work in synergy to …

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

S Serini, G Calviello - Antioxidants, 2024 - mdpi.com
Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term
complication of chemotherapy and one of the more devastating. Most of the studies …

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

YQ He, CC Zhou, SG Jiang, WQ Lan, F Zhang… - Frontiers in …, 2024 - frontiersin.org
Chemotherapy-related cognitive deficits (CRCI) as one of the common adverse drug
reactions during chemotherapy that manifest as memory, attention, and executive function …