Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …

Aims Intravenous iron therapy can improve symptoms in patients with heart failure, anaemia
and iron deficiency. The mechanisms underlying such an improvement might involve …

Abstract TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology
underlying several neurodegenerative diseases. Charting the progression and …

Background and purpose This study sought to evaluate the relationship of progressive
corticospinal tract (CST) degeneration with survival in patients with amyotrophic lateral …

Abstract Objective Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous
neurodegenerative condition featuring variable degrees of motor and cognitive impairment …

Background TDP-43 proteinopathies represent a spectrum of neurological disorders,
anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal …

Background and purpose This study aimed at estimating the prevalence of language
impairment (LI) in a large, clinic‐based cohort of non‐demented amyotrophic lateral …

Background This study aimed at clarifying the role of bulbar involvement (BI) as a risk factor
for cognitive impairment (CI) in non-demented amyotrophic lateral sclerosis (ALS) patients …

Background The present study aimed at (1) providing further validity and reliability evidence
for the Italian version of the cognitive section of the ALS Cognitive Behavioral Screen (ALS …

The present study aimed at deriving, by means of a traditional “2 standard deviation-
based”(2SD) approach, single task-level cutoffs for the Italian version of the Edinburgh …