[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …
highlighting the need for improved drug treatments. In this review an overview of drugs …
DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and …
SL Schaffner, MS Kobor - Frontiers in genetics, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes
N Veiga, Y Diesendruck, D Peer - Advanced Drug Delivery Reviews, 2020 - Elsevier
Abnormalities in leukocytes' function are associated with many immune related disorders,
such as cancer, autoimmunity and susceptibility to infectious diseases. Recent …
such as cancer, autoimmunity and susceptibility to infectious diseases. Recent …
DNA methylation differences associated with social anxiety disorder and early life adversity
A Wiegand, B Kreifelts, MHJ Munk, N Geiselhart… - Translational …, 2021 - nature.com
Social anxiety disorder (SAD) is a psychiatric disorder characterized by extensive fear in
social situations. Multiple genetic and environmental factors are known to contribute to its …
social situations. Multiple genetic and environmental factors are known to contribute to its …
SNPs in sites for DNA methylation, transcription factor binding, and miRNA targets leading to allele-specific gene expression and contributing to complex disease risk …
Introduction: The complex genetic diversity among human populations results from an
assortment of factors acting at various sequential levels, including mutations, population …
assortment of factors acting at various sequential levels, including mutations, population …
Bioinformatic prioritization and functional annotation of GWAS-based candidate genes for primary open-angle glaucoma
Background: Primary open-angle glaucoma (POAG) is the most prevalent glaucoma
subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most …
subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most …
Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variation
Parkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay of
genetic and environmental factors. For the stratification of PD patients and the development …
genetic and environmental factors. For the stratification of PD patients and the development …
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters
Background There is widespread interest in the three-dimensional chromatin conformation
of the genome and its impact on gene expression. However, these studies frequently do not …
of the genome and its impact on gene expression. However, these studies frequently do not …
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin …
Background The aim of this study was to investigate the association between periodontitis
and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation …
and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation …
Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes
YC Chen, YH Tsai, CC Wang, SF Liu, TW Chen… - Scientific Reports, 2021 - nature.com
We hypothesized that epigenetics is a link between smoking/allergen exposures and the
development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of …
development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of …