The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates
all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a …

The current understanding of how specific distributions of histone post-translational
modifications (PTMs) are achieved throughout the chromatin remains incomplete. This …

Long noncoding RNAs (lncRNAs) have been demonstrated to be important regulators
during the osteogenic differentiation of mesenchymal stem cells (MSCs). We analyzed the …

The polymerase-associated factor 1 complex (PAF1C) is a key, post-initiation transcriptional
regulator of both promoter-proximal pausing and productive elongation catalyzed by RNA …

Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting
children and adults. Chemotherapy treatments show high response rates but have …

Objective. Cancer stem-like cells (CSLCs) are closely associated with tumor recurrence,
metastasis, and drug-resistance. PHD-finger domain protein 5A (PHF5A) is related to …

Objective: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer,
characterized by extensive intratumoral heterogeneity. We aimed to systematically …

DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched
mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in …

Cell identity is determined by the transcriptional regulation of a cell‐type‐specific gene
group. The Paf1 complex (Paf1C), an RNA polymerase II‐associating factor, is an important …

Abstract PHF5A (PHD-finger domain protein 5A) is a highly conserved protein comprised of
110 amino acids that belong to PHD zinc finger proteins and is ubiquitously expressed in …