In 2010, the American Heart Association defined a novel construct of cardiovascular health
to promote a paradigm shift from a focus solely on disease treatment to one inclusive of …

Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …

Background: The American Heart Association recently published an updated algorithm for
quantifying cardiovascular health (CVH)—the Life's Essential 8 score. We quantified US …

Background: Cardiovascular disease may be the main reason for stagnant growth in life
expectancy in the United States since 2010. The American Heart Association recently …

Importance Coronary artery calcium score and polygenic risk score have each separately
been proposed as novel markers to identify risk of coronary heart disease (CHD), but no …

Importance The average life expectancy has increased substantially in the past few decades
in most industrialized countries; however, not all of the increased life expectancy is being …

Objective This study assessed cardiovascular health (CVH) in young adults using the 2022
AHA Life's Essential 8 (LE8) score and compared it with the Life's Simple 7 (LS7) score …

Aims To evaluate the independent, mediating, interactive, and associated effects of Life's
Essential 8 (LE8) and genetic predisposition on the risk of cardiovascular outcomes and all …

Chronic and uncleared inflammation is the root cause of various cardiovascular diseases.
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …

Since it was first defined by the American Heart Association in 2010, cardiovascular health
(CVH) has been extensively studied across the life course. In this review, we present the …