Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

RHB Benedict, J DeLuca, G Phillips… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Cognitive and motor performance measures are commonly employed in multiple sclerosis
(MS) research, particularly when the purpose is to determine the efficacy of treatment. The …

Impact of sex hormones on immune function and multiple sclerosis development

MC Ysrraelit, J Correale - Immunology, 2019 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) affecting young people and leading to demyelination and neurodegeneration. The …

Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant

MD Steenwijk, JJG Geurts, M Daams, BM Tijms… - Brain, 2016 - academic.oup.com
Abstract See Chard and Miller (doi: 10.1093/brain/awv354) for a scientific commentary on
this article. Grey matter atrophy is common in multiple sclerosis. However, in contrast with …

Brain MRI atrophy quantification in MS: from methods to clinical application

MA Rocca, M Battaglini, RHB Benedict, N De Stefano… - Neurology, 2017 - AAN Enterprises
Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …

Network collapse and cognitive impairment in multiple sclerosis

MM Schoonheim, KA Meijer, JJG Geurts - Frontiers in neurology, 2015 - frontiersin.org
The current field of multiple sclerosis (MS) research is an active and highly interesting one:
structural abnormalities such as inflammatory lesions and brain atrophy are studied with a …

Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis

MM Schoonheim, HE Hulst, RB Brandt, M Strik… - Neurology, 2015 - AAN Enterprises
Objective: This study investigates whether changes in functional connectivity, diffusivity, and
volume of the thalamus can explain different severities of cognitive impairment in multiple …

The importance of studying sex differences in disease: The example of multiple sclerosis

LC Golden, R Voskuhl - Journal of neuroscience research, 2017 - Wiley Online Library
To date, scientific research has often focused on one sex, with assumptions that study of the
other sex would yield similar results. However, many diseases affect males and females …

Sex differences in brain atrophy in multiple sclerosis

RR Voskuhl, K Patel, F Paul, SM Gold, M Scheel… - Biology of sex …, 2020 - Springer
Background Women are more susceptible to multiple sclerosis (MS) than men by a ratio of
approximately 3: 1. However, being male is a risk factor for worse disability progression …