Multifunctional gold nanoparticles for improved diagnostic and therapeutic applications: a review
The medical properties of metals have been explored for centuries in traditional medicine for
the treatment of infections and diseases and still practiced to date. Platinum-based drugs are …
the treatment of infections and diseases and still practiced to date. Platinum-based drugs are …
Antibiotics in the clinical pipeline in October 2019
MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …
Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
Vancomycin Resistance in Enterococcus and Staphylococcus aureus
Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …
commensals and major opportunistic human pathogens. In recent decades, these bacteria …
[HTML][HTML] Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action
JE Waters, L Stevens-Cullinane, L Siebenmann… - Current Opinion in …, 2023 - Elsevier
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning
threats to public health worldwide. With low economic incentives and a dwindling supply of …
threats to public health worldwide. With low economic incentives and a dwindling supply of …
Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics
Y Liu, Y Lu, Z Xu, X Ma, X Chen, W Liu - Drug Discovery Today, 2022 - Elsevier
Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …
antibiotics. It is also challenging to discover and develop new antibiotics with novel …
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired
infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance …
infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance …
Evaluation of 1, 3, 4-thiadiazole carbonic anhydrase inhibitors for gut decolonization of vancomycin-resistant enterococci
Vancomycin-resistant enterococci (VRE), Enterococcus faecium and Enterococcus faecalis,
are high-priority drug-resistant pathogens in need of new therapeutic approaches. VRE …
are high-priority drug-resistant pathogens in need of new therapeutic approaches. VRE …
In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci
Vancomycin-resistant enterococci (VRE) are a serious public health threat and a leading
cause of healthcare-associated infections. Bacterial resistance to antibiotics recommended …
cause of healthcare-associated infections. Bacterial resistance to antibiotics recommended …
Auranofin and its analogues show potent antimicrobial activity against multidrug‐resistant pathogens: structure–activity relationships
Due to the so‐called “antibiotic resistance crisis” new antibacterial agents are urgently
sought to treat multidrug‐resistant pathogens. A group of gold‐or silver‐based complexes, of …
sought to treat multidrug‐resistant pathogens. A group of gold‐or silver‐based complexes, of …