[HTML][HTML] Corneal repair and regeneration: current concepts and future directions
M Mobaraki, R Abbasi, S Omidian Vandchali… - … in Bioengineering and …, 2019 - frontiersin.org
The cornea is a unique tissue and the most powerful focusing element of the eye, known as
a window to the eye. Infectious or non-infectious diseases might cause severe visual …
a window to the eye. Infectious or non-infectious diseases might cause severe visual …
In vitro cultivation of limbal epithelial stem cells on surface‐modified crosslinked collagen scaffolds
M Haagdorens, V Cėpla, E Melsbach… - Stem cells …, 2019 - Wiley Online Library
Purpose. To investigate the efficacy of recombinant human collagen type I (RHC I) and
collagen‐like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of …
collagen‐like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of …
[HTML][HTML] Comparative study of substrate free and amniotic membrane scaffolds for cultivation of limbal epithelial sheet
Transplantation of cultivated limbal epithelial transplantation has been proven to restore the
corneal surface in limbal stem cell deficiency (LSCD). Here we comparatively investigated …
corneal surface in limbal stem cell deficiency (LSCD). Here we comparatively investigated …
[HTML][HTML] Identification of the regulatory circuit governing corneal epithelial fate determination and disease
JGA Smits, DL Cunha, M Amini, M Bertolin… - PLoS …, 2023 - journals.plos.org
The transparent corneal epithelium in the eye is maintained through the homeostasis
regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on …
regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on …
[HTML][HTML] Xenofree generation of limbal stem cells for ocular surface advanced cell therapy
N Nieto-Nicolau, EM Martínez-Conesa… - Stem cell research & …, 2019 - Springer
Background Limbal stem cells (LSC) sustain the corneal integrity and homeostasis. LSC
deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach …
deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach …
Recent advances in regenerative medicine
Tissue engineering is now preferred as a primary method utilizing cells in various therapies.
The transplantation of cells has been substantially promoted especially in some areas such …
The transplantation of cells has been substantially promoted especially in some areas such …
Optimized protocol for regeneration of the conjunctival epithelium using the cell suspension technique
Purpose: To develop autologous tissue-engineered conjunctival epithelial sheets to be used
as advanced therapy medicinal products for severe ocular surface disorders involving the …
as advanced therapy medicinal products for severe ocular surface disorders involving the …
[HTML][HTML] Expansion of human limbal epithelial stem/progenitor cells using different human sera: a multivariate statistical analysis
R Hernáez-Moya, S González, A Urkaregi… - International Journal of …, 2020 - mdpi.com
Transplantation of human cultured limbal epithelial stem/progenitor cells (LESCs) has
demonstrated to restore the integrity and functionality of the corneal surface in about 76% of …
demonstrated to restore the integrity and functionality of the corneal surface in about 76% of …
[HTML][HTML] Genetic Modification of Limbal Stem Cells to Decrease Allogeneic Immune Responses
E Valdivia, M Bertolin, C Breda… - Frontiers in …, 2021 - frontiersin.org
Limbal stem cell (LSC) transplantation is the only efficient treatment for patients affected by
LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful …
LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful …
Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease
JGA Smits, DL Cunha, M Amini, M Bertolin… - bioRxiv, 2022 - biorxiv.org
The homeostasis of the transparent corneal epithelium in the eye is maintained by limbal
stem cells with proper cell fates. A potential disease mechanism underlying corneal opacity …
stem cells with proper cell fates. A potential disease mechanism underlying corneal opacity …