The kinetochore is a mega-dalton protein assembly that forms within centromeric regions of
chromosomes and directs their segregation during cell division. Here we review cell cycle …

Evolutionarily conserved polo-like kinase, Cdc5 (Plk1 in humans), associates with
kinetochores during mitosis; however, the role of cell cycle–dependent centromeric (CEN) …

The kinetochore, a multi-protein complex assembled on centromeres, is essential to
segregate chromosomes during cell division. Deficiencies in kinetochore function can lead …

Background Colony growth on solid media is a simple and effective measure for high-
throughput genomic experiments such as yeast two-hybrid, synthetic dosage lethality and …

The yeast centrosome or Spindle Pole Body (SPB) is an organelle situated in the nuclear
membrane, where it nucleates spindle microtubules and acts as a signaling hub. Various …

Mammalian cells process information through coordinated spatiotemporal regulation of
proteins. Engineering cellular networks thus relies on efficient tools for regulating protein …

The budding yeast Saccharomyces cerevisiae has long been an outstanding platform for
understanding the biology of eukaryotic cells. Robust genetics, cell biology, molecular …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the highly infectious coronavirus disease COVID-19. Extensive research has been …

Protein phosphorylation regulates multiple cellular processes including cell-cycle
progression, which is driven by highly conserved cyclin-dependent kinases (CDKs). CDKs …

Protein phosphorylation plays an essential role in cell cycle progression. In Saccharomyces
cerevisiae a single cyclin-dependent kinase (CDK) complex is the driving force of the cell …