The role of inflammatory and anti‐inflammatory cytokines in the pathogenesis of osteoarthritis

P Wojdasiewicz, ŁA Poniatowski… - Mediators of …, 2014 - Wiley Online Library
Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

Knee osteoarthritis: a review of management options

SM Hussain, DW Neilly, S Baliga… - Scottish medical …, 2016 - journals.sagepub.com
Osteoarthritis of the knee is a complex peripheral joint disorder with multiple risk factors. The
molecular basis of osteoarthritis has been generally accepted; however, the exact …

Occupational and genetic risk factors for osteoarthritis: a review

B Yucesoy, LE Charles, B Baker, CM Burchfiel - Work, 2015 - content.iospress.com
BACKGROUND: Osteoarthritis (OA) is a multifactorial disease with strong genetic and
occupational components. Although published studies have described several risk factors …

The contribution of genes to osteoarthritis

AM Valdes, TD Spector - Rheumatic Disease Clinics of North America, 2008 - Elsevier
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of
evidence, including familial aggregation and classic twin studies, indicates that primary OA …

Anticytokine therapy for osteoarthritis: evidence to date

CJ Malemud - Drugs & aging, 2010 - Springer
Several recent in vitro investigations and experimental studies performed in animal models
of osteoarthritis (OA) sustained the previously held view that interleukin (IL)-1 or tumour …

Obesity and inflammation-targets for OA therapy

F Iannone, G Lapadula - Current drug targets, 2010 - ingentaconnect.com
Obesity is one of the main risk factors for osteoarthritis (OA). For many years the association
of obesity and OA has been simply attributed to the effects of overload on weight-bearing …

Platelet-rich plasma for articular cartilage repair

GD Abrams, RM Frank, LA Fortier… - Sports medicine and …, 2013 - journals.lww.com
Platelet concentrates have been gaining popularity for a number of applications in
orthopedic surgery as a way to enhance both healing of various tissues and reduce pain …

Elevated IL‐6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells

F Doss, J Menard, M Hauschild… - Scandinavian journal …, 2007 - Taylor & Francis
Objective: To analyse the levels of interleukin‐6 (IL‐6) in the synovial fluids and sera of
patients with osteoarthritis (OA) and to identify the IL‐6‐secreting cells. Methods: Serum …

Genetics in osteoarthritis

M Fernández-Moreno, I Rego… - Current …, 2008 - ingentaconnect.com
Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse
factors interact causing a process of deterioration of the cartilage. Despite the multifactorial …

Relationship between joint shape and the development of osteoarthritis

JC Baker-LePain, NE Lane - Current opinion in rheumatology, 2010 - journals.lww.com
Relationship between joint shape and the development of oste... : Current Opinion in
Rheumatology Relationship between joint shape and the development of osteoarthritis : Current …