Mechanisms and potential clinical implications of oral microbiome in oral squamous cell carcinoma

J Wang, B Gao - Current Oncology, 2023 - mdpi.com
Microorganisms in the oral cavity are abundant in the human body. At present, more than
700 species of oral microorganisms have been identified. Recently, a lot of literature has …

Neutrophils promote tumor progression in oral squamous cell carcinoma by regulating EMT and JAK2/STAT3 signaling through chemerin

X Hu, F Xiang, Y Feng, F Gao, S Ge, C Wang… - Frontiers in …, 2022 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. In
the tumor microenvironment, tumor-associated neutrophils (TANs) can promote tumor …

Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

T Masaki, M Habara, S Hanaki, Y Sato, H Tomiyasu… - Scientific Reports, 2023 - nature.com
Abstract c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or
highly expressed in cancers. However, molecular mechanisms underlying this aberrantly …

Outcome and long‐term treatment protocol for topical tacrolimus in oral lichen planus

S Utz, VGA Suter, S Cazzaniga… - Journal of the …, 2022 - Wiley Online Library
Background and objective Topical tacrolimus has been shown to be beneficial in the
treatment of oral lichen planus (OLP). However, long‐term effects and its optimal application …

Tacrolimus induces apoptosis in leukemia Jurkat cells through inactivation of the reactive oxygen species-dependent phosphoinositide-3-kinase/Akt signaling …

YH Choi - Biotechnology and Bioprocess Engineering, 2022 - Springer
Tacrolimus, also named FK506, widely used as an immunosuppressant, is a kind of
macrolide produced by Streptomyces tsukubaensis. Although tacrolimus is known to induce …

Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma

J Zhou, Z Hu, L Wang, Q Hu, Z Chen, T Lin, R Zhou… - Microbiome, 2024 - Springer
Background Oral squamous cell carcinoma (OSCC) remains a major death cause in head
and neck cancers, but the exact pathogenesis mechanisms of OSCC are largely unclear …

Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer

T Li, X Liu, X Long, Y Li, J Xiang, Y Lv… - Environmental …, 2023 - Wiley Online Library
Objective In the present study, we investigated the role of brexpiprazole on cell proliferation
and lipogenesis in colorectal cancer (CRC) and its molecular mechanism. Methods The …

Immuno‐Isolation Strategy with Tacrolimus‐Loaded Nanofilm Promotes Stable Stem Cell‐Based Cartilage Regeneration

Z Guo, X Zhu, L Xu, J Zhu, X Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Bone marrow stem cells (BMSCs)‐engineered cartilage (BEC) shows promise for clinically
repairing cartilage defects. However, when implanted in immunocompetent large animals …

Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability

T Masaki, M Habara, S Shibutani, S Hanaki… - Biochemical and …, 2023 - Elsevier
The epidermal growth factor receptor (EGFR) is highly expressed or abnormally activated in
several types of cancers, such as lung and colorectal cancers. Inhibitors that suppress the …

Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs

M Gao, W Liu, T Li, ZL Song, XY Wang, XS Zhang - Biochemical Genetics, 2024 - Springer
Osteosarcoma is the most common type of primary malignant bone tumor. Due to the lack of
selectivity and sensitivity of chemotherapy drugs to tumor cells, coupled with the use of large …