In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …

With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …

The World Health Organisation has estimated that by 2015 approximately 2.3 billion adults
will be overweight and more than 700 million obese. Obesity is associated with an increased …

OBJECTIVE Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor
(GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese …

Obesity is one of the major challenges to human health worldwide; however, there are
currently no effective pharmacological interventions for obesity. Recent studies have …

We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and
glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the …

A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by
the distal intestine in response to ingested nutrients. Here we report that in rats, ip injection …

Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that
activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor …

Obesity is one of the greatest public health challenges of the 21st century with 1.6 billion
adults currently classified as being overweight and 400 million as obese. Obesity is causally …