The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

The reversible acetylation of histone lysine residues is controlled by the action of
acetyltransferases and deacetylases (HDACs), which regulate chromatin structure and gene …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging
processes, and they were suggested to mediate the lifespan extending effect of a low calorie …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven
human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are …

Sirtuins are evolutionarily conserved nicotinamide adenine dinucleotide (NAD+)-dependent
lysine deacylases or ADP-ribosyltransferases. These cellular enzymes are metabolic …