Single-cell and spatial molecular profiling assays have shown large gains in sensitivity,
resolution and throughput. Applying these technologies to specimens from human and …

Mouse models are a critical tool for studying human diseases, particularly developmental
disorders. However, conventional approaches for phenotyping may fail to detect subtle …

Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …

Embryonic development is remarkably robust, but temperature stress can degrade its ability
to generate animals with invariant anatomy. Phenotypes associated with environmental …

Introduction Zebrafishes represent a proven model for human diseases and systems
biology, exhibiting physiological and genetic similarities and having innate and adaptive …

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Identifying gene expression differences in heterogeneous tissues across experimental or
observational conditions is a fundamental biological task, enabled by single-cell assays …

The capacity for embryonic cells to differentiate relies on a large-scale reprogramming of the
oocyte and sperm nucleus into a transient totipotent state. In zebrafish, this reprogramming …

Temperature exerts a fundamental influence across scales of biology, from the biophysical
nature of molecules, to the sensitivity of cells, and the coordinated progression of …

Cell type repertoires have expanded extensively in metazoan animals, with some clade-
specific cells being paramount to their evolutionary success. A prime example are the …