The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes
NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation. Most …

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past
several decades have markedly expanded our understanding of its cellular sources and …

Given its critical role in T-cell signaling, interleukin-2–inducible kinase (ITK) is an appealing
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune …

The regulatory circuits that define developmental decisions of thymocytes are still
incompletely resolved. SATB1 protein is predominantly expressed at the CD4+ CD8+ cell …

CRTh2 (encoded by PTGDR2) is a G-protein coupled receptor expressed by Th2 cells as
well as eosinophils, basophils and innate lymphoid cells (ILC) 2s. Activation of CRTh2, by its …

BACKGROUND Cow milk allergy is the most common food allergy in children. So far, no
effective treatment is available to prevent or cure food allergy. This study investigated …

Severe acquired aplastic anaemia (AA) is a serious disease characterised by autoreactive T
cells attacking haematopoietic stem cells, leading to marrow hypoplasia and pancytopenia …

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Invariant NKT (iNKT) cells represent a subset of innate-like T lymphocytes that function as
orchestrators of hepatic inflammation underpinning liver damage. In this study, we …

Abstract Background Gami-Cheongyeul-Sodok-Eum (GCSE), an herbal formula of
traditional Korean medicine, comprises nine herb components. GCSE has various biological …