Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …

CD28 and CTLA-4 are both important stimulatory receptors for the regulation of T cell
activation. Because receptors share common ligands, B7. 1 and B7. 2, the expression and …

Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial joints where different
CD4+ T cell subsets may contribute to pathology. Here, we perform single cell sequencing …

This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …

The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis,
and rheumatoid arthritis is now well established. This had led to the emergence of a modern …

Immune checkpoint inhibitors are associated with immune-related adverse events (irAEs),
including arthritis (arthritis-irAE). Management of arthritis-irAE is challenging because …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Unbiased genetic studies have uncovered surprising molecular mechanisms in human
cellular immunity and autoimmunity. We performed whole-exome sequencing and targeted …