Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

[HTML][HTML] Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention.

E Almanza-Aguilera, A Cano, M Gil-Lespinard… - Seminars in Cancer …, 2023 - Elsevier
Olive oil (OO) is the main source of added fat in the Mediterranean diet (MD). It is a mix of
bioactive compounds, including monounsaturated fatty acids, phytosterols, simple phenols …

[HTML][HTML] Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota

HY Zhang, JX Tian, FM Lian, M Li, WK Liu… - Biomedicine & …, 2021 - Elsevier
Metabolic diseases such as obesity, type 2 diabetes mellitus, and hyperlipidemia are
associated with the dysfunction of gut microbiota. Traditional Chinese medicines (TCMs) …

[HTML][HTML] Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

D Li, Y Lu, S Yuan, X Cai, Y He, J Chen, Q Wu… - The American journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics

M Shanmugham, S Bellanger, CH Leo - Pharmaceuticals, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …

[HTML][HTML] Advances in multi-omics study of biomarkers of glycolipid metabolism disorder

X Fang, R Miao, J Wei, H Wu, J Tian - Computational and Structural …, 2022 - Elsevier
Glycolipid metabolism disorder are major threats to human health and life. Genetic,
environmental, psychological, cellular, and molecular factors contribute to their …

Contribution of trimethylamine N-oxide (TMAO) to chronic inflammatory and degenerative diseases

LA Constantino-Jonapa, Y Espinoza-Palacios… - Biomedicines, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has
been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in …

Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose–response meta-analysis

MA Farhangi, M Vajdi, M Asghari-Jafarabadi - Nutrition journal, 2020 - Springer
Aims Several epidemiological studies have examined the association between
trimethylamine N-Oxide (TMAO) and stroke risk; however, the results are still inconclusive …

Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide

RL Loo, Q Chan, JK Nicholson… - Journal of Proteome …, 2022 - ACS Publications
Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …

Role of the gut microbiome in the development of atherosclerotic cardiovascular disease

A Al Samarraie, M Pichette, G Rousseau - International Journal of …, 2023 - mdpi.com
Atherosclerotic cardiovascular disease (ASCVD) is the primary cause of death globally, with
nine million deaths directly attributable to ischemic heart diseases in 2020. Since the last …