Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

A number of different methods are commonly used to map the fine details of the interaction
between an antigen and an antibody. Undoubtedly the method that is now most commonly …

Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

The increasing resistance of many microbial strains to antibiotics, delayed laboratory results,
and side effects of many chemotherapeutics has raised the need to search for sensitive …

Mass spectrometric epitope mapping has become a versatile method to precisely determine
a soluble antigen's partial structure that directly interacts with an antibody in solution. Typical …

Highlights•Introductory bases and equations of HDX-MS.•Protein dynamics explored by
HDX-MS.•Representative case studies that measured by HDX-MS.•Future directions of HDX …

The development of anti-drug antibodies (ADAs) following administration of biotherapeutics
to patients is a vexing problem that is attracting increasing attention from pharmaceutical …

Protein therapeutics have emerged as a major class of biopharmaceuticals over the past
several decades, a trend that has motivated the advancement of bioanalytical technologies …

Antibody drug conjugates (ADCs) are highly cytotoxic drugs covalently attached via
conditionally stable linkers to monoclonal antibodies (mAbs) and are among the most …

Introduction: Mass spectrometry (MS) is widely used in the characterization of biomolecules
including peptide and protein therapeutics. These biotechnology products have seen rapid …